Dobermann Health Issues
Autoimmune Hemolytic Anaemia [AIHA]
In hemolytic anaemia, a loss of red blood cells [rbcs] occurs due to destruction of the red blood cells. The destruction occurs due to antibodies which stick to the rbcs and cause the body to react, leading to destruction of the cell. This can be the direct result of a drug, toxin, blood parasite, virus or other primary cause - or it can be an unexplained immune mediated reaction. It can occur inside the blood stream [intravascular hemolysis] or outside the bloodstream [extra vascular hemolysis]. In most cases in dogs, hemolysis occurs outside the blood stream in the spleen, liver and bone marrow. The destruction of red blood cells often leaves recognisable cellular debris in the blood stream. In particular, a form of damaged rbc known as a spherocyte occurs. Finding spherocytes on a blood smear almost guarantees that some form of hemolytic anaemia is occurring. However, it does not really give a clue as to whether the IMHA is due to a primary cause, or if it is occurring for no apparent reason. Since this disorder does not stop the production of red blood cells, there are usually immature red blood cells in the bloodstream which can be detected on the blood smears as well [a regenerative anaemia].
Dilated Cardiomyopathy [DCM]
With this condition, the heart is enlarged and compensatory mechanisms are acting to maintain blood flow. The dog will initially have no clinical symptoms - but it will eventually exhibit lethargy, will tire easily [due to the heart not being able to pump enough blood around the body], start coughing [fluid in lungs], or other similar symptoms [basically the symptoms of congestive heart failure].
There is no cure for dilated cardiomyopathy, but there are treatments that will improve cardiac function which will deninish the clinical symptoms. The typical treatment consists of enalapril [angiotensin converting enzyme inhibitor], lasix [diuretic], and digoxin [improves the contractility of the heart to make it function better]. The treatment, in addition to lessening the clinical manifestations of the disease, may prolong the dog's life. Since cardiomyapathy is a progressive disease, treatment prior to the appearance of clinical symptoms may slow down the progression and increase the dog's life expectancy.
Healthy Heart Checks for DOBERMANNs!
Leading veterinary cardiologists are looking for owners of purebred Dobermanns (between 5 and 9 years old, in good health), who would be willing to allow their dog to be screened for early signs of heart disease.
One or more common causes of heart disease in dogs is dilated cardiomyopathy. Here the heart muscle becomes flabby and weak, so that eventually the heart is unable to pump effectively. This can take many months or years, meaning that the dog may have heart disease for a long time before visible symptoms can be seen by the vet and owner. However, eventually it results in the appearance of signs of heart failure, such as weakness, exercise tolerance, difficulty breathing, coughing and weight loss.
The condition is most common in large (e.g. Dobermanns) and giant (e.g. Great Danes) breeds of dogs. The cardiologists are specifically interested in the effects of the disease in Dobermanns, and a medication (pimobendan) that may delay the onset of symptoms of heart failure. This medication is already licensed, and widely used to manage the symptoms of heart failure in dogs once they arise.
If you are interested in taking part in this study and your dog is suitable for screening, you will be offered a free of charge consultation and a detailed diagnostic examination by one of the UK’s leading veterinary cardiologists. Should your dog be identified as having the hidden signs of dilated cardiomyopathy, it will then enter a free long term trial.
For further information, or if you would be interested in helping with this study, please contact your veterinary surgeon, or phone the PROTECT information line on 01344 742574 and leave your details. Thank you.
Hypothyroidism
A hormonal disorder usually occurring in dogs that are around 2-5 years old. Clinical signs are lethargy, hair loss, bacterial skin infections, excessive skin pigmentation, coarseness of the hair, and obesity. Dogs affected will be lethargic and will tend to feel the cold more. This conidtion can be diagnosed by means of a simple blood test.
Hip Dysplasia [HIPS]
Hip dysplasia means, literally, an abnormality in the development of the hip joint, and it is characterized by a shallow acetabulum [the 'cup' of the hip joint], together with changes in the shape of the femoral head [the 'ball' of the hip joint]. These changes may occur due to excessive laxity in the hip joint. Hip dysplasia can exist with or without clinical signs. When dogs exhibit clinical signs of this problem they are usually lame on one or both rear limbs.
Severe arthritis can develop as a result of the malformation of the hip joint, and this results in pain as the disease progresses. Many young dogs exhibit pain during or shortly after the growth period, often before arthritic changes appear to be present. It is not unusual for this pain to appear to disappear for several years and then to return when arthritic changes become obvious.
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